BLINK enables ultrafast tandem mass spectrometry cosine similarity scoring

BLINK enables ultrafast tandem mass spectrometry cosine similarity scoring

Blog Article

Abstract Metabolomics has a long history of using cosine similarity to match experimental tandem mass spectra to databases for compound identification.Here we introduce the Blur-and-Link (BLINK) approach for scoring cosine similarity.By bypassing fragment Maternity Tops alignment and simultaneously scoring all pairs of spectra using sparse matrix operations, BLINK is over 3000 times faster than MatchMS, a widely used loop-based alignment and scoring implementation.Using a similarity cutoff of 0.

7, BLINK and MatchMS had practically equivalent identification agreement, and greater than 99% of their scores and matching ion counts were Dishwasher Front Escutcheon Panel identical.This performance improvement can enable calculations to be performed that would typically be limited by time and available computational resources.